Müller N
MMW Munch Med Wochenschr. 1979 Nov 9;121(45):1485-8.
The development of transfusion medicine started from the attempts to transfuse blood in animals in the 17th century and the first fruits were seen in the second half of the 19th century. About 1800, however, Blundell introduced a new development which brought fundamental changes with the elucidation of the problems of defibrination, the phenomenon of hemolysis and coagulation. At the beginning of the 20th century the serological problems were solved by Landsteiner's discoveries. The introduction of anticoagulation permitted the conservation of blood and led to the discontinuation of direct blood transfusion in favour of indirect transfusion of conserved blood. This considerably enlarged the functions and possibilites of transfusion medicine which opened into the development of blood component therapy with its opportunities for optimal care of the patients.
输血医学的发展始于17世纪在动物身上进行输血的尝试，19世纪下半叶初见成效。然而，大约在1800年，布伦德尔带来了一项新进展，随着对去纤维蛋白、溶血和凝血现象等问题的阐明，这带来了根本性的变化。20世纪初，兰德施泰纳的发现解决了血清学问题。抗凝剂的引入使得血液得以保存，并导致直接输血被间接输注保存的血液所取代。这极大地扩展了输血医学的功能和可能性，为血液成分治疗的发展及其为患者提供最佳护理的机会开辟了道路。
