Georgiadis M C, Kostoglou M
Centre for Research and Technology - Hellas, Chemical Process Engineering Research Institute, P.O. Box 361, Thermi 57001, Thessaloniki, Greece.
J Control Release. 2001 Dec 13;77(3):273-85. doi: 10.1016/s0168-3659(01)00510-7.
This work presents a systematic optimization framework to achieve desired release rates in drug delivery devices using multi-laminated layers. A simple mathematical model is used to describe the transient mass transfer between successive layers, laminated together to form matrices with different initial concentrations, drug diffusivities and thickness. First, an efficient analytical-based optimization approach is investigated to define the optimal nonuniform initial drug distribution for constant diffusivity profile. The results obtained are in a good agreement with relevant work from the literature resorting to advanced optimal control techniques. Then, a formal dynamic optimization approach is employed, to systematically explore the synergistic benefits when all the available controllable parameters are simultaneously optimized, in order to achieve a drug release profile as close to a desired profile as possible for the entire period of operation. The optimization results lead to significantly improved constant release profiles.
这项工作提出了一个系统优化框架，以利用多层结构在药物输送装置中实现所需的释放速率。一个简单的数学模型用于描述连续层之间的瞬态传质，这些层叠在一起形成具有不同初始浓度、药物扩散率和厚度的基质。首先，研究了一种基于分析的高效优化方法，以确定恒定扩散率分布下的最佳非均匀初始药物分布。所得结果与文献中采用先进最优控制技术的相关工作高度一致。然后，采用一种形式化的动态优化方法，系统地探索当所有可用可控参数同时优化时的协同效益，以便在整个运行期间实现尽可能接近所需曲线的药物释放曲线。优化结果显著改善了恒释曲线。
