血管加压素对大鼠视上核去甲肾上腺素释放具有差异性调节作用。
Vasopressin differentially modulates noradrenaline release in the rat supraoptic nucleus.
作者信息
Yamashita T, Liu X, Onaka T, Honda K, Saito T, Yagi K
机构信息
Department of Physiology, Jichi Medical School, Tochigi-ken 329-0498, Japan.
出版信息
Neuroreport. 2001 Nov 16;12(16):3509-11. doi: 10.1097/00001756-200111160-00027.
Vasopressin is released not only from axon terminals in the neurohypophysis but also from soma/dendrite regions in the supraoptic nucleus. In order to investigate presynaptic roles of dendritically released vasopressin, we examined effects of local application of vasopressin upon noradrenaline release within the supraoptic nucleus by a microdialysis method. Noradrenaline release within the supraoptic nucleus was facilitated by local perfusion with high K+ or an NMDA receptor antagonist. Vasopressin augmented noradrenaline increase after high K+ but reduced it after an NMDA receptor antagonist, AP-5. The results suggest that dendritically released vasopressin modulates noradrenaline release within the supraoptic nucleus in a bimodal fashion.
血管加压素不仅从神经垂体的轴突终末释放，也从视上核的胞体/树突区域释放。为了研究树突释放的血管加压素的突触前作用，我们通过微透析法检测了局部应用血管加压素对视上核内去甲肾上腺素释放的影响。视上核内的去甲肾上腺素释放可通过局部灌注高钾或NMDA受体拮抗剂来促进。血管加压素在高钾灌注后增强了去甲肾上腺素的增加，但在NMDA受体拮抗剂AP-5灌注后则降低了去甲肾上腺素的增加。结果表明，树突释放的血管加压素以双峰方式调节视上核内的去甲肾上腺素释放。
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