Geisler J P, Sorosky J I, Duong H L, Buekers T E, Geisler M J, Sood A K, Anderson B, Buller R E
Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.
Gynecol Oncol. 2001 Dec;83(3):501-3. doi: 10.1006/gyno.2001.6445.
Some women with endometrial cancer may be at increased risk for developing breast cancer. The histologic type of endometrial cancer associated with synchronous or subsequent breast cancer has not been clearly established. Our purpose was to determine if a certain histologic type of endometrial cancer was associated with an increased risk of synchronous or subsequent breast cancer.
The University of Iowa Hospitals and Clinics tumor registry was queried to ascertain all patients with the diagnosis of uterine cancer from January 1, 1983, to December 31, 1994. Statistics were performed utilizing SPSS for Windows version 9.0 (SPSS Inc., Chicago, IL), including Student's t tests and chi(2) tests.
Five hundred ninety-two patients had endometrial adenocarcinoma during the study period. Five hundred thirty-six women had endometrioid adenocarcinoma, 23 women had papillary serous carcinoma (UPSC), 21 women had adenosquamous carcinoma, 10 women had clear-cell carcinoma, and 1 woman each had mucinous or squamous carcinoma. Twelve patients had previously been diagnosed with breast carcinomas. Twenty-five patients were diagnosed with breast cancer either concurrently or subsequent to their diagnosis of endometrial cancer. Synchronous or subsequent breast cancers developed in 3.2% of patients with endometrioid carcinoma and in 25% of patients with UPSC (P < 0.001).
Patients with UPSC have an increased risk of development of breast cancer as compared to patients with endometrioid adenocarcinoma of the uterus.
一些子宫内膜癌女性患乳腺癌的风险可能会增加。与同步或后续乳腺癌相关的子宫内膜癌组织学类型尚未明确确定。我们的目的是确定某种组织学类型的子宫内膜癌是否与同步或后续乳腺癌风险增加相关。
查询爱荷华大学医院及诊所肿瘤登记处，以确定1983年1月1日至1994年12月31日期间所有诊断为子宫癌的患者。使用SPSS for Windows 9.0版（SPSS公司，伊利诺伊州芝加哥）进行统计分析，包括Student's t检验和卡方检验。
在研究期间，592例患者患有子宫内膜腺癌。536例女性患有子宫内膜样腺癌，23例女性患有乳头状浆液性癌（UPSC），21例女性患有腺鳞癌，10例女性患有透明细胞癌，1例女性分别患有黏液性或鳞状癌。12例患者先前被诊断患有乳腺癌。25例患者在诊断子宫内膜癌的同时或之后被诊断患有乳腺癌。子宫内膜样癌患者中3.2%发生同步或后续乳腺癌，UPSC患者中25%发生同步或后续乳腺癌（P<0.001）。
与子宫子宫内膜样腺癌患者相比，UPSC患者患乳腺癌的风险增加。
