实验性心肌梗死后生长激素和胰岛素样生长因子-I在大鼠体内的类似心血管效应。

Similar cardiovascular effects of growth hormone and insulin-like growth factor-I in rats after experimental myocardial infarction.

作者信息

Tivesten A, Caidahl K, Kujacic V, Sun X Y, Hedner T, Bengtsson B A, Isgaard J

机构信息

Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Gröna Stråket 8, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden.

出版信息

Growth Horm IGF Res. 2001 Jun;11(3):187-95. doi: 10.1054/ghir.2001.0202.

DOI:10.1054/ghir.2001.0202

PMID:11735233

Abstract

Accumulating data show that growth hormone (GH) and insulin-like growth factor-I (IGF-I) have major effects on the cardiovascular system. In the present study we have directly compared GH and IGF-I in an in vivo rat model of experimental myocardial infarction. Four weeks after ligation of the left coronary artery, male rats were treated with recombinant human (rh) GH 1.1 mg/kg per day, rhIGF-I 3.0 mg/kg per day or saline s.c. for 2 weeks. Transthoracic echocardiography was performed before and after the treatment period. Both GH and IGF-I reduced total peripheral resistance (P< 0.01), end-systolic wall stress (P< 0.01) and end-systolic short-axis area (P< 0.001 and P< 0.05). GH also increased area fractional shortening (P< 0.05). Stroke volume (SV) and SV index were improved by IGF-I (P< 0.0001), and SV tended to be increased by GH (P= 0.12). In conclusion, GH and IGF-I had similar beneficial effects on systolic function and peripheral resistance after experimental myocardial infarction.

摘要

越来越多的数据表明，生长激素（GH）和胰岛素样生长因子-I（IGF-I）对心血管系统有重大影响。在本研究中，我们在实验性心肌梗死的大鼠体内模型中直接比较了GH和IGF-I。左冠状动脉结扎4周后，雄性大鼠每天皮下注射重组人生长激素（rhGH）1.1mg/kg、重组人胰岛素样生长因子-I（rhIGF-I）3.0mg/kg或生理盐水，持续2周。在治疗期前后进行经胸超声心动图检查。GH和IGF-I均降低了总外周阻力（P<0.01）、收缩末期壁应力（P<0.01）和收缩末期短轴面积（P<0.001和P<0.05）。GH还增加了面积缩短分数（P<0.05）。IGF-I改善了每搏输出量（SV）和SV指数（P<0.0001），GH使SV有增加的趋势（P=0.12）。总之，在实验性心肌梗死后，GH和IGF-I对收缩功能和外周阻力具有相似的有益作用。