Zaina S, Pettersson L
Experimental Cardiovascular Research, Wallenberg Laboratory, Department of Medicine, University of Lund, Malmö, Sweden.
Growth Horm IGF Res. 2001 Oct;11(5):298-302. doi: 10.1054/ghir.2001.0241.
The peptide insulin-like growth factor II (IGF-II) is a foetal promoter of growth and differentiation. Genetically modified mice have provided insights into the contribution of IGF-II to the determination of the size of the body and individual organs. Nevertheless, the role of IGF-II in regulating the size of major blood vessels is poorly understood. Here, the transverse luminal and medial area of the aorta and the number of medial cell nuclei are shown not to be significantly different in adult wild-type and Igf2 nullizygous mice, despite a approximately 30% reduction in BW in the latter group. The observations in this study suggest that IGF-II is not an indispensable factor in the determination of the size of the aortic lumen, and are consistent with the view that growth factor redundancy may be a safeguard mechanism to maintain the size of the aorta within a range compatible with viability.
肽类胰岛素样生长因子II（IGF-II）是胎儿生长和分化的促进因子。基因改造小鼠有助于深入了解IGF-II对身体及各器官大小的影响。然而，IGF-II在调节主要血管大小方面的作用仍知之甚少。在此研究中，尽管成年野生型小鼠与Igf2基因敲除小鼠的体重相差约30%，但研究显示，两组小鼠主动脉的横截面积、中膜面积及中膜细胞核数量并无显著差异。本研究结果表明，IGF-II并非决定主动脉管腔大小的必需因子，这一观点与生长因子冗余可能是维持主动脉大小在与生存能力相适应范围内的一种保护机制的看法相符。
