Classen J B, Classen D C
Classen Immunotherapies Inc., 6517 Montrose Avenue, Baltimore, MD 21212, USA.
Med Hypotheses. 2001 Nov;57(5):532-8. doi: 10.1054/mehy.2001.1352.
Immunization with a number of different vaccines, including live and killed vaccines, has been linked to the development of insulin-dependent (type 1) diabetes in humans and animals. Multiple different mechanisms have been proposed to explain the association between vaccines and diabetes. The current paper reviews multiple different mechanisms by which vaccines are known to manipulate the immune system and can induce an autoimmune disease such as type 1 diabetes. Genetic variability may determine which of these pathways, or possible other pathways, predominate in an individual following immunization.
接种多种不同的疫苗，包括活疫苗和灭活疫苗，已被证明与人类和动物中胰岛素依赖型（1型）糖尿病的发生有关。人们提出了多种不同的机制来解释疫苗与糖尿病之间的关联。本文综述了多种不同的机制，通过这些机制已知疫苗可操纵免疫系统并能诱发自身免疫性疾病，如1型糖尿病。基因变异性可能决定在免疫接种后个体中这些途径中的哪一种，或可能的其他途径占主导地位。
