鸡肾小管对三乙胆碱（TEC）的排泄：TEC对胆碱和乙酰胆碱肾排泄的增强与抑制作用
Renal tubular excretion of triethylcholine (TEC) in the chicken: enhancement and inhibition of renal excretion of choline and acetylcholine by TEC.
作者信息
Acara M, Kowalski M, Rennick B, Hemsworth B
出版信息
Br J Pharmacol. 1975 May;54(1):41-8. doi: 10.1111/j.1476-5381.1975.tb07407.x.
Abstract
- [3H]-triethylcholine (TEC) was actively transported by the renal tubule of the chicken at a rate 85% that of simultaneously administered p-aminohippuric acid (PAH). 2. TEC was demonstrated to be transported by the organic cation transport system in the kidney through inhibition with quinine and the bio-cation choline. 3. When the infusion of TEC was increased to 2 times 10(-6) mol kg(-1) min(-1) reaching the infused kidney, the transport of [3H]-TEC was inhibited, suggesting that an excretory transport maximum for TEC in the renal tubules had been reached. 4. The excretion of both choline and acetylcholine was enhanced by TEC loads as low as 1 times 10(-18) mol kg(-1) min(-1). Enhancement continued as TEC infusion was increased up to approximately 1 times 10(-7) mol kg(-1) min(-1) at which point this enhancement was converted to inhibition. 5. Possible mechanisms for the biphasic effect of TEC on organic cation transport are discussed.
摘要
- [3H]-三乙胆碱（TEC）由鸡的肾小管以同时给予的对氨基马尿酸（PAH）速率的85%进行主动转运。2. 通过奎宁和生物阳离子胆碱的抑制作用，证明TEC在肾脏中由有机阳离子转运系统转运。3. 当TEC的输注量增加到2×10⁻⁶mol·kg⁻¹·min⁻¹到达灌注的肾脏时，[3H]-TEC的转运受到抑制，表明肾小管中TEC的排泄转运最大值已达到。4. 低至1×10⁻¹⁸mol·kg⁻¹·min⁻¹的TEC负荷即可增强胆碱和乙酰胆碱的排泄。随着TEC输注量增加至约1×10⁻⁷mol·kg⁻¹·min⁻¹，这种增强作用持续存在，此时这种增强作用转变为抑制作用。5. 讨论了TEC对有机阳离子转运产生双相效应的可能机制。
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Renal tubular excretion of triethylcholine (TEC) in the chicken: enhancement and inhibition of renal excretion of choline and acetylcholine by TEC.鸡肾小管对三乙胆碱（TEC）的排泄：TEC对胆碱和乙酰胆碱肾排泄的增强与抑制作用
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