Brown J M
J Can Assoc Radiol. 1975 Mar;26(1):35-9.
An evaluation is made of the conflicting claims of large and small animals as models in experimental radiotherapy. The pro's and con's of each are examined in relationship to both tumor and normal tissue studies. It is concluded that there are few, if any, tumor-related studies in which large animals are preferable, and that a somewhat similar situation exists with investigations of early reactions on normal tissues (at least to the extent that these are governed by the cell survival curve). The conclusion emerges, however, that a large animal may be required in certain investigations of late effects. Examples of the very different late effect tolerance levels between mouse and man are given.
对大型动物和小型动物作为实验放射治疗模型的相互矛盾的主张进行了评估。分别从肿瘤和正常组织研究的角度审视了各自的优缺点。得出的结论是，在与肿瘤相关的研究中，很少（如果有的话）有大型动物更具优势的情况，而且在正常组织早期反应的研究中（至少在这些反应受细胞存活曲线支配的程度上）情况也大致相似。然而，结论是在某些晚期效应的研究中可能需要大型动物。给出了小鼠和人类之间晚期效应耐受水平差异极大的例子。
