Xu Y, Seet L F, Hanson B, Hong W
Membrane Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore.
Biochem J. 2001 Dec 15;360(Pt 3):513-30. doi: 10.1042/0264-6021:3600513.
Phosphoinositides are key regulators of diverse cellular processes. The pleckstrin homology (PH) domain mediates the action of PtdIns(3,4)P(2), PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3), while the FYVE domain relays the pulse of PtdIns3P. The recent establishment that the Phox homology (PX) domain interacts with PtdIns3P and other phosphoinositides suggests another mechanism by which phosphoinositides can regulate/integrate multiple cellular events via a spectrum of PX domain-containing proteins. Together with the recent discovery that the epsin N-terminal homologue (ENTH) domain interacts with PtdIns(4,5)P(2), it is becoming clear that phosphoinositides regulate diverse cellular events through interactions with several distinct structural motifs present in many different proteins.
磷酸肌醇是多种细胞过程的关键调节因子。普列克底物蛋白同源（PH）结构域介导磷脂酰肌醇-4,5-二磷酸（PtdIns(4,5)P(2)）、磷脂酰肌醇-3,4-二磷酸（PtdIns(3,4)P(2)）和磷脂酰肌醇-3,4,5-三磷酸（PtdIns(3,4,5)P(3)）的作用，而FYVE结构域传递磷脂酰肌醇-3-磷酸（PtdIns3P）的信号。最近证实，Phox同源（PX）结构域与PtdIns3P和其他磷酸肌醇相互作用，这提示了磷酸肌醇可通过一系列含PX结构域的蛋白质调节/整合多种细胞事件的另一种机制。连同最近发现的发动蛋白N端同源物（ENTH）结构域与PtdIns(4,5)P(2)相互作用一起，越来越清楚的是，磷酸肌醇通过与许多不同蛋白质中存在的几种不同结构基序相互作用来调节多种细胞事件。
