[红天精毒素B对大鼠肝脏线粒体呼吸的影响]

[Effect of rubratoxin B on the respiration of liver mitochondria in the rat].

作者信息

Bernard C, Dumas P

出版信息

Mycopathologia. 1975 Feb 28;55(1):53-5. doi: 10.1007/BF00467092.

Abstract

The in vitro effect of rubratoxin B on the electron transport system of rat liver mitochondira was investigated. This mycotoxin depressed oxygen consumption in ADP-lacking mitochondira and in ADP-coupled mitochondria, using succinate or beta-hydroxybutyrate as substrats. Rubratoxin B is neither an oxidative-phosphorylation inhibitor nor uncoupling agent. Its effect is compared with aflatoxin B1.

摘要

研究了红天精毒素B对大鼠肝脏线粒体电子传递系统的体外作用。使用琥珀酸或β-羟基丁酸作为底物时，这种霉菌毒素会降低缺乏ADP的线粒体和与ADP偶联的线粒体中的氧气消耗。红天精毒素B既不是氧化磷酸化抑制剂，也不是解偶联剂。将其作用与黄曲霉毒素B1进行了比较。