Iniesta J A, Corral J, González-Conejero R, Díaz Ortuño A, Martínez Navarro M L, Vicente V
Neurology Services, Hospital General Universitario, Murcia, Spain.
Cephalalgia. 2001 Oct;21(8):837-41. doi: 10.1046/j.0333-1024.2001.00273.x.
At present, it is contradictory to determine if the combination of certain prothrombotic polymorphisms and migraine increases the risk to develop ischaemic cerebrovascular disease. Recently, the common Val34Leu polymorphism of the A-chain factor XIII gene, associated with variations in factor XIII activity, has been suggested to play a significant role in the development of arterial and venous thrombotic disorders. We analysed the prevalence of this polymorphism in 17 patients with coexisting ischaemic cerebrovascular disease and migraine (5 with aura, and 12 without aura), 89 patients with migraine (43 with aura, and 46 without aura), 116 patients with ischaemic cerebrovascular disease, and 467 healthy Caucasian controls from the South of Spain. Genomic PCR amplification, using a mutated oligonucleotide, and allele-specific restriction assays were used for genotyping. The factor XIII Leu 34 variant was present in 47.1; 40.5; 34.9; and 35.1% of patients with coexisting ischaemic cerebrovascular disease and migraine, ischaemic cerebrovascular disease, migraine, and control subjects, respectively. These data suggest that the factor XIII Leu 34 allele does not play a protective role against these disorders in our population.
目前，确定某些促血栓形成多态性与偏头痛的组合是否会增加发生缺血性脑血管疾病的风险存在矛盾。最近，与因子 XIII 活性变化相关的 A 链因子 XIII 基因常见的 Val34Leu 多态性，被认为在动脉和静脉血栓形成性疾病的发展中起重要作用。我们分析了 17 例合并缺血性脑血管疾病和偏头痛的患者（5 例有先兆，12 例无先兆）、89 例偏头痛患者（43 例有先兆，46 例无先兆）、116 例缺血性脑血管疾病患者以及来自西班牙南部的 467 名健康白种人对照中这种多态性的患病率。使用突变的寡核苷酸进行基因组 PCR 扩增，并采用等位基因特异性限制性分析进行基因分型。因子 XIII Leu 34 变体分别在合并缺血性脑血管疾病和偏头痛的患者、缺血性脑血管疾病患者、偏头痛患者以及对照人群中的比例为 47.1%、40.5%、34.9% 和 35.1%。这些数据表明，在我们的人群中，因子 XIII Leu 34 等位基因对这些疾病没有起到保护作用。
