Boeckle H, Oechslen D, Lüttgen F, Lindenmaier K
Arzneimittelforschung. 1975 Jan;25(1):120-2.
Thirty patients with histologically ascertained blomerulonephritis and proteinuria were treated over an average period of 4 months with 750 mg/die 2-m-trigluoromethylanilino-nicotinic acid (niflumic acid, Actol). The following was shown: 1. In 73% of the cases the proteinuria diminished. 2. Kidney function remained unchanged, that is, it worsened only in such cases in which there was already limited functioning. 3. In case of initially increased values the secretion of fibrinogen degradation products diminished in 70% of the cases. 4. When the medication was stopped, its effects vanished. Niflumic acid shows to be an effective drug in the treatment of the nephrotic syndrome and the number of complications is smaller due to the improved condition of protein metabolism. Therefore, this form of treatment, in certain ways, influences the prognosis of the disease.
30例经组织学确诊为肾小球肾炎和蛋白尿的患者，平均治疗4个月，每日服用750毫克2-间三氟甲基苯胺基烟酸（氟尼酸，Actol）。结果表明：1. 73%的病例蛋白尿减少。2. 肾功能保持不变，即仅在已有功能受限的病例中恶化。3. 初始值升高的病例中，70%的病例纤维蛋白原降解产物分泌减少。4. 停药后，其效果消失。氟尼酸显示出是治疗肾病综合征的有效药物，且由于蛋白质代谢状况改善，并发症数量较少。因此，这种治疗方式在某些方面影响疾病的预后。
