Saint-Ruf G, Hieu H T
Arzneimittelforschung. 1975 Jan;25(1):66-8.
In continuation of our pharmacological research on the in vivo induction or inhibition of the drug metabolizing enzymes system, a series of 32 derivatives of indole bearing aryl substituents in position 2 and 3 were investigated in regard to their effect on the in vivo synthesis of zoxazolamine hydroxylase in the young rat. Most fo the compounds examined proved to be inducers of this enzyme; however, as is the case with polycyclic carcinogens, the inducing activity was found to be significantly dependent on molecular structure.
作为我们对药物代谢酶系统体内诱导或抑制的药理学研究的延续，我们研究了一系列在2位和3位带有芳基取代基的32种吲哚衍生物对幼鼠体内唑沙胺羟化酶合成的影响。所检测的大多数化合物被证明是这种酶的诱导剂；然而，与多环致癌物的情况一样，发现诱导活性显著依赖于分子结构。
