Klein G
Arzneimittelforschung. 1975 Feb;25(2A):288-91.
d-2-(6'Methoxy-2'-naphthyl)-propionic acid (naproxen) in different concentrations was investigated as to its influence on the semiconservative DNA synthesis and DNA repair of human lymphocytes and mouse speen cells. As could be shown, there was a slight diminuation of the DNA synthesis. In view of a desired antiproliferating effect in the treatment of rheumatic diseases this fact could certainly prove useful. Additionally, with a naproxen concentration of 30 ppm, a diminuation of the endonuclease activity in mouse spleen cells could be shown. With naproxen concentrations higher than 60 ppm a slight lowering of the exonuclease and polymerase activities in mouse spleen cells as well as in human lymphocytes were observed. With naproxen in a concentration of 120 ppm, all three enzymes of the excision repair investigated showed a distinct loss of activity. Results of investigations on ligase activity will be presented separately. Under the administration of naproxen, late effects on the genetic material are rather improbable, as long as the substance is not admininstered concomitantly with agents which have a direct effect on the DNA.
研究了不同浓度的d - 2 -（6'-甲氧基-2'-萘基）-丙酸（萘普生）对人淋巴细胞和小鼠脾细胞的半保留DNA合成及DNA修复的影响。结果表明，DNA合成略有减少。鉴于在风湿性疾病治疗中期望的抗增殖作用，这一事实无疑可能是有用的。此外，当萘普生浓度为30 ppm时，可显示小鼠脾细胞中的内切核酸酶活性降低。当萘普生浓度高于60 ppm时，观察到小鼠脾细胞以及人淋巴细胞中的外切核酸酶和聚合酶活性略有降低。当萘普生浓度为120 ppm时，所研究的切除修复的所有三种酶均显示出明显的活性丧失。关于连接酶活性的研究结果将另行公布。在萘普生给药的情况下，只要该物质不与对DNA有直接作用的药物同时给药，对遗传物质的后期影响相当不可能发生。
