Tausch G
Arzneimittelforschung. 1975 Feb;25(2A):291-2.
This investigation was conducted in order to evaluate the possibility of late defects caused by drugs. After their base-line blood levels had been assessed, 3 patients with classical rheumatoid arthritis (according to ARA criteria; American Rheumatism Association) received 500 mg of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) daily (in capsules). At the peak of naproxen blood levels following the first naproxen dose, and once monthly for 7 months, thereafter, blood samples were drawn. After separating the lymphocytes from the whole blood, they were damaged by means of 60-Co. Hydroxyurea was added for the suppression of their semiconservative DNA-synthesis. The incorporation of 3-H-THYMIDINE INTO THE DNA of the cells was measured after radiation at different incubation periods. The results showed normal behaviour of the DNA-synthesis following naproxen administration in all three patients. The DNA-repair capacity was normal in one female patient, but slightly lowered in the remaining two.
进行这项调查是为了评估药物导致晚期缺陷的可能性。在评估了3例典型类风湿关节炎患者（根据美国风湿病协会的ARA标准）的基线血药浓度后，他们每日服用500毫克d - 2 -（6'-甲氧基-2'-萘基）-丙酸（萘普生）（胶囊剂型）。在首次服用萘普生后血药浓度达到峰值时，以及此后7个月每月一次，采集血样。从全血中分离出淋巴细胞后，用60钴对其进行损伤。加入羟基脲以抑制其半保留DNA合成。在不同孵育期进行辐射后，测量3 - H -胸苷掺入细胞DNA的情况。结果显示，所有3例患者服用萘普生后DNA合成表现正常。1例女性患者的DNA修复能力正常，其余2例略有降低。
