健康婴儿的血浆胶体渗透压

Plasma colloid osmotic pressure in healthy infants.

作者信息

Sussmane J B, de Soto M, Torbati D

机构信息

Division of Critical Care Medicine, Miami Children's Hospital, Miami, Florida, USA.

出版信息

Crit Care. 2001 Oct;5(5):261-4. doi: 10.1186/cc1043. Epub 2001 Aug 9.

DOI:10.1186/cc1043

PMID:11737900

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC83852/

Abstract

BACKGROUND

The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This study was designed to test whether plasma COP values in healthy infants are the same as those in normal adults.

METHODS

Plasma COP was measured in 37 male and female healthy infants from 1 to 11 months old. For this purpose, 1 ml blood was collected during the patient's regularly scheduled visit if the patient required any type of blood test for routine laboratory analyses.

RESULTS

Plasma COP levels correlated slightly with increasing age from 1 to 9 months old (linear regression analysis; r2 = 0.1, P < 0.049). We found no correlation between plasma COP and body weight at the same age (r2 = 0.05, P = 0.155). The mean and standard deviation of COP in all infants was 25.1 +/- 2.6 mmHg, which is almost identical to an average COP of 25 mmHg in healthy adult subjects. Arbitrary division of the infants into three different age groups (1-3 months [n = 11], 5-8 months [n = 13] and 9-11 months [n = 13]) showed an average increase of approximately 2 mmHg in COP of 9-month-old to 11-month-old infants, compared with 1-month-old to 3-month-old infants (one-way analysis of variance; P = 0.26). There was no gender difference in the COP level (unpaired t-test), with an average of 25.1 +/- 2.4 mmHg in 19 male infants compared with 25.2 +/- 2.9 in 18 female infants. The 95% confidence interval for COP in both male and female infants (n = 37) was between 24.3 to 26.0 mmHg, ranging from 19.5 to 30.3 mmHg, with a median value of 25.2 mmHg.

CONCLUSIONS

The data accept the null hypothesis that the COP range in infants younger than 1 year old is similar to those observed in adult subjects. Our observations, compared with previously reported neonatal COP values, suggest that there is a sharp increase in COP within the first months after birth.

摘要

背景

血浆胶体渗透压（COP）在毛细血管间液体平衡中起主要作用。关于出生后第一周以后健康婴儿的血浆COP尚无相关信息。目前健康成年受试者的正常COP（25 mmHg）也被用作健康婴儿的参考值。本研究旨在测试健康婴儿的血浆COP值是否与正常成年人相同。

方法

对37名1至11个月大的健康男婴和女婴测量血浆COP。为此，如果患者需要进行任何类型的血液检查以进行常规实验室分析，则在患者定期就诊时采集1 ml血液。

结果

1至9个月大的婴儿，血浆COP水平随年龄增长略有相关（线性回归分析；r2 = 0.1，P < 0.049）。我们发现在同一年龄段血浆COP与体重之间无相关性（r2 = 0.05，P = 0.155）。所有婴儿COP的平均值和标准差为25.1±2.6 mmHg，这与健康成年受试者的平均COP 25 mmHg几乎相同。将婴儿任意分为三个不同年龄组（1至3个月[n = 11]、5至8个月[n = 13]和9至11个月[n = 13]），结果显示，与1至3个月大的婴儿相比，9至11个月大的婴儿COP平均升高约2 mmHg（单因素方差分析；P = 0.26）。COP水平无性别差异（非配对t检验），19名男婴的平均COP为25.1±2.4 mmHg，18名女婴为25.2±2.9 mmHg。37名男婴和女婴COP的95%置信区间在24.3至26.0 mmHg之间，范围为19.5至30.3 mmHg，中位数为25.2 mmHg。