来自银杏叶的香豆酰黄酮醇苷

Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba.

作者信息

Tang Y, Lou F, Wang J, Li Y, Zhuang S

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210038, PR China.

出版信息

Phytochemistry. 2001 Dec;58(8):1251-6. doi: 10.1016/s0031-9422(01)00320-x.

DOI:10.1016/s0031-9422(01)00320-x

PMID:11738417

Abstract

Two coumaroyl flavonol glycosides, isorhamnetin 3-O-alpha-L-[6"'-p-coumaroyl-(beta-D)-glucopyranosyl-(1,2)-rhamnopyranoside], and kaempferol 3-O-alpha-L-[6"'-p-coumaroyl-(beta-D)-glucopyranosyl-(1,2)-rhamnopyranoside]-7-O-beta-D-glucopyranoside, were isolated from the n-BuOH extract of Ginkgo biloba leaves. These two, together with six other flavonol glycosides, kaempferol 3-O-alpha-L-[6"'-p-coumaroyl-(beta-D)-glucopyranosyl-(1,2)-rhamnopyranoside], quercetin 3-O-alpha-L-[6"'-p-coumaroyl-(beta-D)-glucopyranosyl-(1,2)-rhamnopyranoside], quercetin 3-O-alpha-L-[6"'-p-coumaroyl-(beta-D)-glucopyranosyl-(1,2)-rhamnopyranoside]-7-O-beta-D-glucopyranoside, quercetin 3-O-beta-D-glucopyranosyl-(1-2)-alpha-L-rhamnopyranoside, quercetin 3-O-beta-rutinoside, and quercetin 3-O-beta-D-glucopyranoside, showed profound antioxidant activities in DPPH and cytochrome-c reduction assays using the HL-60 cell culture system.

摘要

从银杏叶正丁醇提取物中分离出两种香豆酰黄酮醇糖苷，异鼠李素3 - O-α-L-[6''-对香豆酰基-(β-D)-吡喃葡萄糖基-(1,2)-鼠李吡喃糖苷]和山奈酚3 - O-α-L-[6''-对香豆酰基-(β-D)-吡喃葡萄糖基-(1,2)-鼠李吡喃糖苷]-7 - O-β-D-吡喃葡萄糖苷。这两种糖苷与其他六种黄酮醇糖苷，即山奈酚3 - O-α-L-[6''-对香豆酰基-(β-D)-吡喃葡萄糖基-(1,2)-鼠李吡喃糖苷]、槲皮素3 - O-α-L-[6''-对香豆酰基-(β-D)-吡喃葡萄糖基-(1,2)-鼠李吡喃糖苷]、槲皮素3 - O-α-L-[6''-对香豆酰基-(β-D)-吡喃葡萄糖基-(1,2)-鼠李吡喃糖苷]-7 - O-β-D-吡喃葡萄糖苷、槲皮素3 - O-β-D-吡喃葡萄糖基-(1-2)-α-L-鼠李吡喃糖苷、槲皮素3 - O-β-芸香糖苷和槲皮素3 - O-β-D-吡喃葡萄糖苷，在使用HL-60细胞培养系统的DPPH和细胞色素c还原试验中表现出显著的抗氧化活性。