Cho Hyun-Jong, Yoon In-Soo
College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea.
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, 1666 Youngsan-ro, Muan-gun, Jeonnam 534-729, Republic of Korea.
Evid Based Complement Alternat Med. 2015;2015:736431. doi: 10.1155/2015/736431. Epub 2015 Jan 6.
The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively. Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used herbs can provide robust fundamentals for optimizing CYP and/or P-gp substrate drug-based therapy. Herein, we review ten popular medicinal and/or dietary herbs as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions. The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in several in vitro and in vivo animal and human systems.
在过去十年中，药物与草药产品的同时使用变得越来越普遍。已知几种草药产品可调节细胞色素P450（CYP）酶和P-糖蛋白（P-gp），它们分别被认为是代表性的药物代谢酶和药物转运蛋白。因此，关于常用草药对CYP和P-gp调节作用的知识总结可为优化基于CYP和/或P-gp底物药物的治疗提供坚实的基础。在此，我们综述了十种常见的药用和/或食用草药，它们是CYP和P-gp介导的药代动力学草药-药物相互作用的引发因素。主要关注先前关于草药提取物及其植物化学物质在几种体外和体内动物及人体系统中调节CYP和P-gp表达及功能能力的研究。
