Tucciarone L, Tomassini A, Colasanti A, Sabbi T, Iacobini M, El Hachem M
Istituto di Clinica Pediatrica, Università degli Studi La Sapienza, Rome, Italy.
Minerva Pediatr. 2001 Dec;53(6):581-6.
The case of a healthy and immunocompetent five-year-old boy, who developed a disseminated intravascular coagulation during chickenpox is described. Disseminated intravascular coagulation manifestations were extremely severe and included macroscopic hematuria, necrotic purpura and cerebrovascular thrombosis. The outcome in this patient was a complete recovery. Nevertheless, the possibility of a seriously complicated course of chickenpox even in low-risk children subgroups suggests that the Varicella-Zoster virus infection should not be underestimated. More accurate information about the impact of chickenpox and its complications on the population is needed, in order to provide a contribution for the debate about the costs associated with this disease and the potential benefits of both the early antiviral therapy and the vaccinal prophylaxis.
本文描述了一名免疫功能正常的健康5岁男孩，在水痘期间发生弥散性血管内凝血的病例。弥散性血管内凝血的表现极其严重，包括肉眼血尿、坏死性紫癜和脑血管血栓形成。该患者最终完全康复。然而，即使在低风险儿童亚组中，水痘也可能出现严重并发症，这表明水痘-带状疱疹病毒感染不容小觑。为了有助于讨论与该疾病相关的成本以及早期抗病毒治疗和疫苗预防的潜在益处，需要更准确地了解水痘及其并发症对人群的影响。
