Soubrier M, Dubost J J, Ristori J M, Sauvezie B, Bussière J L
Université de Médecine-Hôpital G. Montpied, France.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Dec;92(6):637-40. doi: 10.1067/moe.2001.119739.
Diffuse sclerosing osteomyelitis of the mandible is characterized by bouts of intense pain, sometimes associated with trismus and paresthesia, and leads to progressive deformity. It is of unknown etiopathology, but it is suggested to be one manifestation of the synovitis, acne, pustulosis, hyperostosis, osteomyelitis syndrome, the other features of which may have been overlooked. Treatment results are disappointing, and decortication may be necessary to achieve an acceptable outcome. We report a case restricted to the mandible that responded favorably to treatment with pamidronate. Further trials of pamidronate in patients with diffuse sclerosing osteomyelitis of the mandible, even in those with the aforementioned syndrome, are needed to assess its effectiveness.
下颌骨弥漫性硬化性骨髓炎的特征为阵发性剧痛，有时伴有牙关紧闭和感觉异常，并导致进行性畸形。其病因病理不明，但有人认为它是滑膜炎、痤疮、脓疱病、骨肥厚、骨髓炎综合征的一种表现形式，该综合征的其他特征可能被忽视了。治疗效果令人失望，可能需要进行骨皮质剥除术才能取得可接受的结果。我们报告了1例局限于下颌骨的病例，其对帕米膦酸盐治疗反应良好。需要对下颌骨弥漫性硬化性骨髓炎患者，甚至是患有上述综合征的患者，进一步进行帕米膦酸盐试验，以评估其有效性。
