Hack C E
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands.
Semin Thromb Hemost. 2001 Dec;27(6):633-8. doi: 10.1055/s-2001-18867.
Studies in experimental models for sepsis, the most common cause of disseminated intravascular coagulation (DIC), have put forward the concept of a procoagulant state that is characterized by thrombin generation exceeding that of plasmin. Convincing evidence indicates that this imbalance between coagulation and fibrinolysis is due to increased levels of plasminogen activator inhibitor type 1 (PAI-1). Levels of this fibrinolysis inhibitor indeed correlate with outcome and severity of multiple organ failure in patients with sepsis, as well as in patients with DIC from other causes. Hence we suggest that PAI-1 constitutes an important target for therapy in patients with DIC.
脓毒症是弥散性血管内凝血（DIC）最常见的病因，针对脓毒症实验模型的研究提出了促凝状态的概念，其特征是凝血酶生成超过纤溶酶。确凿证据表明，凝血与纤溶之间的这种失衡是由于1型纤溶酶原激活物抑制剂（PAI-1）水平升高所致。在脓毒症患者以及其他病因所致DIC患者中，这种纤溶抑制剂的水平确实与多器官功能衰竭的结局及严重程度相关。因此，我们认为PAI-1是DIC患者治疗的一个重要靶点。
