Funayama H, Mayanagi H, Takada H, Endo Y
Department of Pharmacology and Pediatric Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan.
J Infect Dis. 2001 Dec 15;184(12):1566-71. doi: 10.1086/324663. Epub 2001 Dec 3.
Intragingival (ig) injection into mice of lipopolysaccharide (LPS) from Prevotella intermedia or Escherichia coli elevated the activity of the histamine-forming enzyme, histidine decarboxylase (HDC), in the mandible, liver, lung, and spleen, with a time course similar to that seen with intravenous (iv) injection. The effect of i.g. injection was less than that of i.v. injection but similar to that of intraperitoneal (ip) injection. The i.g. injection also increased hepatic serotonin, reflecting platelet accumulation. In galactosamine-treated mice, the minimum ig dose of LPS needed to induce lethal hepatitis was very small (less than that needed by ip injection). These results support the idea that the LPS produced in oral tissues may be transported easily to extraoral tissues and, in some cases, may cause inflammatory or immune responses. It also may influence the pathogenesis of some systemic diseases.
将中间普氏菌或大肠杆菌的脂多糖（LPS）经牙龈内（ig）注射到小鼠体内，可提高下颌骨、肝脏、肺和脾脏中组胺形成酶——组氨酸脱羧酶（HDC）的活性，其时间进程与静脉内（iv）注射所见相似。牙龈内注射的效果小于静脉内注射，但与腹腔内（ip）注射相似。牙龈内注射还会增加肝脏中的血清素，反映出血小板的积累。在半乳糖胺处理的小鼠中，诱导致死性肝炎所需的LPS最小牙龈内剂量非常小（小于腹腔内注射所需剂量）。这些结果支持以下观点：口腔组织中产生的LPS可能很容易转运到口腔外组织，并且在某些情况下可能引起炎症或免疫反应。它也可能影响某些全身性疾病的发病机制。
