Niimi M, Mochizuki T, Cacabelos R, Yamatodani A
Department of Molecular Physiology, Osaka University, Faculty of Medicine, Japan.
Methods Find Exp Clin Pharmacol. 1993 Oct;15(8):509-14.
The effect of intracerebroventricular (icv) administration of lipopolysaccharide on histidine decarboxylase activity and histamine content in the hypothalamus were investigated in male mice of ddY strain in vivo. Two-fold increase in histidine decarboxylase activity (HDC) was observed 4 h after administration of 50 mcg lipopolysaccharide, and HDC activity returned to the basal level within 12 h after injection. Furthermore, histamine contents showed a slight decrease at 1 and 2 h and a mild increase at 12 h after administration. However, changes in histamine content were not statistically significant. These results suggest that the increase of HDC activity in the hypothalamus by lipopolysaccharide may be involved in the central neuroimmune responses.
在ddY品系雄性小鼠体内，研究了脑室内注射脂多糖对下丘脑组氨酸脱羧酶活性和组胺含量的影响。注射50微克脂多糖4小时后，观察到组氨酸脱羧酶活性（HDC）增加了两倍，注射后12小时内HDC活性恢复到基础水平。此外，给药后1小时和2小时组胺含量略有下降，12小时时略有增加。然而，组胺含量的变化无统计学意义。这些结果表明，脂多糖引起的下丘脑HDC活性增加可能参与了中枢神经免疫反应。
