Rasmussen R A, Montefiori D C, Robinson H L, McClure H M, Ruprecht R M
Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115-6084, USA.
J Infect Dis. 2001 Dec 15;184(12):1603-7. doi: 10.1086/324582. Epub 2001 Dec 3.
According to the principle of original antigenic sin, neutralizing antibodies (NAbs) initially directed against a single virus strain compromise the immune system's ability to subsequently mount adequate responses against antigenically divergent virus strains. In this study, rhesus macaques, after vaccination and breakthrough infection with homologous simian-human immunodeficiency virus (SHIV), developed strong SHIV-IIIB strain-directed NAb responses that were mostly V3 loop specific. After superinfection with heterologous SHIV89.6P, all macaques developed high-titer SHIV89.6P-specific NAbs without significant boosting of SHIV-IIIB-specific NAbs. These results indicate that prior B cell responses against a single immunodeficiency virus strain do not preclude the later development of NAbs against a divergent strain of the same virus.
根据原始抗原罪的原理，最初针对单一病毒株的中和抗体（NAbs）会损害免疫系统随后对抗原性不同的病毒株产生充分反应的能力。在本研究中，恒河猴在接种疫苗并经同源猿猴-人类免疫缺陷病毒（SHIV）突破性感染后，产生了强烈的针对SHIV-IIIB株的NAb反应，这些反应大多是V3环特异性的。在用异源SHIV89.6P进行重复感染后，所有猕猴都产生了高滴度的SHIV89.6P特异性NAb，而SHIV-IIIB特异性NAb没有显著增强。这些结果表明，先前针对单一免疫缺陷病毒株的B细胞反应并不排除后来针对同一病毒的不同株产生NAb。
