Kivinen S, Ylikorkala O, Puukka M
Obstet Gynecol. 1979 Dec;54(6):695-8.
Maternal serum prolactin level (PRL) was determined with radioimmunoassay in normal and complicated late pregnancy. The mean basal PRL levels were not statistically different among normal (179.3 ng/ml), preeclamptic (169.7 ng/ml), hypertensive (171.4 ng/ml), twin (194.8 ng/ml), or diabetic pregnancies (134.4 ng/ml), although 3 of 17 diabetic women had abnormally low PRL levels. The PRL response to 200 micrograms of intravenously administered thyrotropin-releasing hormone (TRH) was investigated and found similar in normal, preeclamptic, hypertensive, and twin pregnancies. There was no response to TRH in 2 of 3 diabetics with a low basal PRL level. One of these diabetic patients experienced an unexplained intrauterine death 4 weeks later; the others delivered term infants, 1 of whom died of respiratory distress syndrome (RDS). These preliminary results suggest that low basal PRL levels and unresponsiveness to TRH may be related to a poor fetal or neonatal prognosis in diabetic pregnancies.
采用放射免疫分析法测定正常晚期妊娠及合并症晚期妊娠孕妇血清催乳素水平（PRL）。正常妊娠（179.3 ng/ml）、先兆子痫妊娠（169.7 ng/ml）、高血压妊娠（171.4 ng/ml）、双胎妊娠（194.8 ng/ml）或糖尿病妊娠（134.4 ng/ml）的平均基础PRL水平在统计学上无差异，尽管17例糖尿病孕妇中有3例PRL水平异常低。研究了静脉注射200微克促甲状腺激素释放激素（TRH）后PRL的反应，发现正常妊娠、先兆子痫妊娠、高血压妊娠和双胎妊娠的反应相似。3例基础PRL水平低的糖尿病患者中有2例对TRH无反应。其中1例糖尿病患者在4周后发生不明原因的宫内死亡；其他患者足月分娩，其中1例死于呼吸窘迫综合征（RDS）。这些初步结果表明，基础PRL水平低及对TRH无反应可能与糖尿病妊娠胎儿或新生儿预后不良有关。
