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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.对于过度表达HER2的转移性乳腺癌，使用化疗加一种抗HER2单克隆抗体进行治疗。
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Inhibition of proliferation and induction of apoptosis in soft tissue sarcoma cells by interferon-alpha and retinoids.α-干扰素和维甲酸对软组织肉瘤细胞增殖的抑制及凋亡的诱导作用
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抗Her-2/neu抗体可诱导Her-2/neu过表达的乳腺癌细胞凋亡，且与p53状态无关。

Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.

作者信息

Brodowicz T, Kandioler D, Tomek S, Ludwig C, Rudas M, Kunstfeld R, Koestler W, Hejna M, Budinsky A, Wiltschke C, Zielinski C C

机构信息

Clinical Division of Oncology, University Hospital, Vienna, Austria.

出版信息

Br J Cancer. 2001 Nov 30;85(11):1764-70. doi: 10.1054/bjoc.2001.2197.

DOI:10.1054/bjoc.2001.2197
PMID:11742500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2363971/
Abstract

Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressing human breast cancer cell lines SK-BR-3, HTB-24, HTB-25, HTB-27, HTB-128, HTB-130 and HTB-131 in relation to p53 genotype and bcl-2 status. SK-BR-3, HTB-24, HTB-128 and HTB-130 cells exhibited mutant p53, whereas wild type p53 was found in HTB-25, HTB-27 and HTB-131 cells. All seven cell lines weakly expressed bcl-2 protein (10-20%). Anti-Her-2/neu antibody, irrespective of p53 and bcl-2 status, induced apoptosis in all 7 cell lines dose- and time-dependently and correlated with Her-2/neu overexpression. In addition, incubation of cell lines with anti-Her-2/neu antibody did not alter p53 or bcl-2 expression. Anti-HER-2/neu antibody did not induce apoptosis in HER-2/neu negative HBL-100 and HTB-132 cell lines. Our results indicate that within the panel of tested breast cancer cell lines, anti-Her-2/neu antibody-induced apoptosis was independent from the presence of intact p53.

摘要

已知抗Her-2/neu抗体可诱导HER-2/neu过表达的乳腺癌细胞发生凋亡。然而，介导和控制这一现象的确切调控机制仍不清楚。在本研究中，我们研究了抗Her-2/neu抗体对HER-2/neu过表达的人乳腺癌细胞系SK-BR-3、HTB-24、HTB-25、HTB-27、HTB-128、HTB-130和HTB-131凋亡的影响，这些细胞系与p53基因型和bcl-2状态有关。SK-BR-3、HTB-24、HTB-128和HTB-130细胞表现出p53突变，而在HTB-25、HTB-27和HTB-131细胞中发现野生型p53。所有七个细胞系均弱表达bcl-2蛋白（10%-20%）。抗Her-2/neu抗体，无论p53和bcl-2状态如何，均能剂量和时间依赖性地诱导所有7个细胞系发生凋亡，且与Her-2/neu过表达相关。此外，用抗Her-2/neu抗体孵育细胞系不会改变p53或bcl-2的表达。抗HER-2/neu抗体不会诱导HER-2/neu阴性的HBL-100和HTB-132细胞系发生凋亡。我们的结果表明，在测试的乳腺癌细胞系中，抗Her-2/neu抗体诱导的凋亡与完整p53的存在无关。