Boccadoro B, Leonardi L, Calvari A R
Arzneimittelforschung. 1975 Jun;25(6):905-16.
A radiological study has been carried out in the dog to control the influence of N-ethyl-2(2-methoxy-5-sulfamido-benzamidomethyl)-pyrrolidine (sulpiride) on the motility of the gastrointestinal tract. The drug was administered orally and parenterally at different doses for each pharmaceutical form and for such route of doses for each pharmaceutical form and for each route of administration. In doses which were considered optimal, the results have demonstrated that sulpiride exerts hypertonic and hyperphasic effects on the smooth musculature of the gastrointestinal tract. Consequently, there is a reduction of the transit time and of the emptying of the opaque meal in the various sectors of the gastrointestinal tract, which is in the order of about 50% with respect to normal. Using doses which are inferior to those considered optimal, no significant results were obtained, while following higher doses the action of sulpiride is manifested by an inhibitory effect on gastrointestinal motility.
为了控制N-乙基-2(2-甲氧基-5-磺酰胺基-苯甲酰胺甲基)-吡咯烷（舒必利）对犬胃肠道运动的影响，已经进行了一项放射学研究。每种剂型和每种给药途径都以不同剂量口服和非肠道给药。在被认为是最佳剂量的情况下，结果表明舒必利对胃肠道平滑肌产生高渗和高相作用。因此，胃肠道各部位的通过时间和不透X线餐的排空减少，相对于正常情况约为50%。使用低于最佳剂量时，未获得显著结果，而使用更高剂量时，舒必利的作用表现为对胃肠动力的抑制作用。
