Karmaus W
Department of Epidemiology, Michigan State University, East Lansing, Michigan 48823, USA.
Environ Health Perspect. 2001 Dec;109 Suppl 6(Suppl 6):863-9. doi: 10.1289/ehp.01109s6863.
Our knowledge about the distribution of exposures to toxic chemicals in various communities is limited. Only about 6% of approximately 1,400 toxic chemicals have been identified in surveys. Even for those chemicals that are measured, information is often insufficient to identify smaller populations at high risk. The question is whether information about the distribution of diseases in communities can help identify environmental risks, indicate areas of concern, and thus substitute exposure information. Thyroid disorders represent a large group of diseases that cannot be recorded into registries because of the lack of clear caseness; community-based monitoring of subtle health effects is needed. Thus, to identify potential health risks in communities, epidemiologic studies including effect and human exposure monitoring are necessary. However, to overcome the limitation of nonsystematic case studies, the development of a network of exposed communities concerned about exposures is proposed. A network would provide assessments of exposures and health outcomes, with different communities mutually serving as exposed and control groups. Such a network would foster communication and prevention measures within communities often left out of the dissemination of information about risks identified in studies conducted with residents of these communities.
我们对有毒化学物质在不同社区的暴露分布情况了解有限。在大约1400种有毒化学物质中,仅有约6%在调查中得到确认。即便对于那些已被检测的化学物质,相关信息往往也不足以识别出高风险的较小群体。问题在于,社区疾病分布信息能否有助于识别环境风险、指出问题所在,进而替代暴露信息。甲状腺疾病是一大类因缺乏明确病例而无法录入登记系统的疾病,因此需要基于社区对细微健康影响进行监测。所以,为了识别社区中的潜在健康风险,开展包括效应监测和人体暴露监测在内的流行病学研究很有必要。然而,为克服非系统性案例研究的局限性,建议建立一个关注暴露情况的受影响社区网络。该网络将提供暴露评估和健康结果评估,不同社区相互作为暴露组和对照组。这样一个网络将促进社区内部的交流与预防措施,而这些社区在有关与本社区居民开展的研究中所识别出的风险信息传播过程中,往往被遗漏。