Ozaki M, Minami K, Sata T, Shigematsu A
Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan.
Can J Anaesth. 2001 Dec;48(11):1080-3. doi: 10.1007/BF03020373.
To evaluate prospectively the incidence and severity of postoperative sore throat in 63 orotracheally intubated patients undergoing general anesthesia for various surgical procedures and to determine whether postoperative sore throat could be attenuated by treatment with the transdermal nonsteroidal anti-inflammatory drug ketoprofen applied on the anterior skin of the neck during operation.
Patients were randomly assigned to have treatment with ketoprofen (ketoprofen group) or to have placebo tape treatment (control group). Postoperative analgesia was obtained by continuous epidural infusion of local anesthetics, and no narcotics were administered intraoperatively or postoperatively. All patients were interviewed postoperatively after 12-20 hr using a scoring scale questionnaire. Sore throat was scored as 0=no sore throat, 1=minimal, 2=mild, 3=moderate, 4=severe.
In the control group, 16 of 32 patients had a sore throat. In the ketoprofen group, less patients (ten of 31 patients) had a sore throat (not significant). The severity of sore throat was alleviated significantly in the ketoprofen group (P <0.05).
This study suggests the pain caused by tracheal intubation is relieved by intraoperative topical use of transdermal ketoprofen.
前瞻性评估63例接受各种外科手术全身麻醉的经口气管插管患者术后咽痛的发生率和严重程度，并确定术中在颈部前方皮肤应用透皮非甾体抗炎药酮洛芬治疗是否可减轻术后咽痛。
患者被随机分配接受酮洛芬治疗（酮洛芬组）或接受安慰剂贴剂治疗（对照组）。通过持续硬膜外输注局部麻醉药获得术后镇痛，术中及术后均未使用麻醉剂。所有患者在术后12 - 20小时使用评分量表问卷进行访谈。咽痛评分为0 =无咽痛，1 =轻微，2 =轻度，3 =中度，4 =重度。
对照组32例患者中有16例出现咽痛。酮洛芬组出现咽痛的患者较少（31例患者中有10例）（差异无统计学意义）。酮洛芬组咽痛的严重程度明显减轻（P <0.05）。
本研究表明术中局部应用透皮酮洛芬可缓解气管插管引起的疼痛。
