Evans H S, Lewis C M, Robinson D, Bell C M, Møller H, Hodgson S V
Thames Cancer Registry, Division of Medicine, Guy's, King's and St. Thomas' School of Medicine, London, United Kingdom.
Int J Cancer. 2001 Dec 1;94(5):758-9. doi: 10.1002/ijc.1534.
Women diagnosed with 2 cancers of the breast and/or ovary are at higher risk of developing subsequent cancers. Using registrations from the Thames Cancer Registry, we quantified the risks at different cancer sites. Increased risks were found for cancers that are part of the BRCA1 and BRCA2 tumour spectrum: oropharyngeal cancer, malignant melanoma of the skin (BRCA2) and colon cancer (BRCA1). We also found significantly increased risks of myeloid leukaemia (probably due to radiotherapy) and of cancer of the corpus uteri (which may be due to hormonal factors).
被诊断患有乳腺癌和/或卵巢癌的女性患后续癌症的风险更高。利用泰晤士癌症登记处的登记数据，我们对不同癌症部位的风险进行了量化。发现与BRCA1和BRCA2肿瘤谱相关的癌症风险增加：口咽癌、皮肤恶性黑色素瘤（BRCA2相关）和结肠癌（BRCA1相关）。我们还发现髓系白血病（可能由于放疗）和子宫体癌（可能由于激素因素）的风险显著增加。
