Roberts W J, Sloan K B
Department of Medicinal Chemistry, P.O. Box 100485, University of Florida, Gainesville, FL 32610, USA.
J Pharm Sci. 2001 Sep;90(9):1318-23. doi: 10.1002/jps.1084.
Data developed by Wenkers and Lippold for the flux of 10 nonsteroidal anti-inflammatory drugs from light mineral oil (MO) through human skin in vivo has been analyzed using the transformed Potts-Guy equation. The analysis shows that the flux is dependent not only on the solubility in MO (S(MO)), but also on the solubility in acidic water (S(AQ)). This dependence of flux on S(AQ) shows that the previously reported dependence of flux on S(AQ) from in vitro experiments using hairless mouse skin is not an artifact of the in vitro experiments but is due to a characteristic of the skin barrier. Further inspection of the equations used by Wenkers and Lippold in their analyses of their data shows that the equations are variations of the transformed Potts-Guy equation.
温克斯和利波尔德所得到的关于10种非甾体抗炎药在体内从轻质矿物油（MO）透过人体皮肤的通量数据，已使用变换后的波茨 - 盖伊方程进行了分析。分析表明，通量不仅取决于在MO中的溶解度（S(MO)），还取决于在酸性水中的溶解度（S(AQ)）。通量对S(AQ)的这种依赖性表明，先前报道的在使用无毛小鼠皮肤的体外实验中通量对S(AQ)的依赖性并非体外实验的人为因素，而是由于皮肤屏障的特性所致。对温克斯和利波尔德在分析其数据时所使用的方程进行进一步检查发现，这些方程是变换后的波茨 - 盖伊方程的变体。
