Yelon D
Developmental Genetics Program, Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.
Dev Dyn. 2001 Dec;222(4):552-63. doi: 10.1002/dvdy.1243.
Development of the embryonic vertebrate heart requires the precise coordination of pattern formation and cell movement. Taking advantage of the availability of zebrafish mutations that disrupt cardiogenesis, several groups have identified key regulators of specific aspects of cardiac patterning and morphogenesis. Several genes, including gata5, fgf8, bmp2b, one-eyed pinhead, and hand2, have been shown to be relevant to the patterning events that regulate myocardial differentiation. Studies of mutants with morphogenetic defects have indicated at least six genes that are essential for cardiac fusion and heart tube assembly, including casanova, bonnie and clyde, gata5, one-eyed pinhead, hand2, miles apart, and heart and soul. Furthermore, analysis of the jekyll gene has indicated its important role during the morphogenesis of the atrioventricular valve. Altogether, these data provide a substantial foundation for future investigations of cardiac patterning, cardiac morphogenesis, and the relationship between these processes.
胚胎脊椎动物心脏的发育需要模式形成和细胞运动的精确协调。利用破坏心脏发生的斑马鱼突变体，几个研究小组已经确定了心脏模式形成和形态发生特定方面的关键调节因子。包括gata5、fgf8、bmp2b、独眼针头和hand2在内的几个基因已被证明与调节心肌分化的模式形成事件有关。对具有形态发生缺陷的突变体的研究表明，至少有六个基因对心脏融合和心管组装至关重要，包括卡萨诺瓦、邦妮和克莱德、gata5、独眼针头、hand2、相隔甚远和心灵。此外，对jekyll基因的分析表明了它在房室瓣形态发生过程中的重要作用。总之，这些数据为未来心脏模式形成、心脏形态发生以及这些过程之间关系的研究提供了坚实的基础。
