Propping P, Friedl W
Psychopharmacology (Berl). 1979 Nov;65(3):265-72. doi: 10.1007/BF00492214.
Platelet monoamine oxidase (MAO) is under genetic control. A lower MAO activity in chronic schizophrenia has repeatedly been reported, and it has been suggested that reduced activity of this enzyme reflects an increased vulnerability to schizophrenia. To test this hypothesis platelet MAO was determined in 65 first-degree relatives of 22 schizophrenic index patients and in matched healthy controls. No difference in mean activity between the two samples could be detected, suggesting that reduced MAO activity in schizophrenia is more likely to be a phenomenon secondary to the disease. A significant parent-offspring correlation of MAO activities was obtained.
血小板单胺氧化酶（MAO）受基因控制。慢性精神分裂症患者中MAO活性较低这一情况已被多次报道，有人提出该酶活性降低反映出患精神分裂症的易感性增加。为验证这一假设，对22名精神分裂症指数患者的65名一级亲属以及匹配的健康对照者测定了血小板MAO。未检测到两个样本之间平均活性存在差异，这表明精神分裂症患者MAO活性降低更可能是该疾病继发的一种现象。MAO活性在亲子间存在显著相关性。
