抗蠕虫药耐药性检测方法。
Anthelmintic resistance detection methods.
作者信息
Taylor M A, Hunt K R, Goodyear K L
机构信息
Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK.
出版信息
Vet Parasitol. 2002 Jan 28;103(3):183-94. doi: 10.1016/s0304-4017(01)00604-5.
The development of species and populations of parasitic helminths with resistance to one or more anthelmintics is an increasing problem world-wide. The majority of currently available anthelmintics used to control parasitic nematodes of cattle and sheep belong to only three main groups, the benzimidazoles, imidazothiazoles and the avermectins/milbemycins. The successful implementation of helminth control programmes designed to limit the development of resistance in nematode populations depends to some degree on the availability of effective and sensitive methods for its detection and monitoring. A variety of in vivo and in vitro tests have been developed for the detection of nematode populations resistant to the main anthelmintic groups, but each suffers to some degree from reliability, reproducibility, sensitivity and ease of interpretation. This review covers those tests that have been reported and described and highlights some of their strengths and weaknesses.
寄生性蠕虫对一种或多种驱虫药产生抗性的物种和种群的发展在全球范围内是一个日益严重的问题。目前用于控制牛羊寄生线虫的大多数驱虫药仅属于三个主要类别，即苯并咪唑类、咪唑噻唑类以及阿维菌素/米尔倍霉素类。旨在限制线虫种群中抗性发展的蠕虫控制计划的成功实施在一定程度上取决于用于检测和监测抗性的有效且灵敏方法的可用性。已经开发了多种体内和体外试验来检测对线虫主要驱虫药类别产生抗性的线虫种群，但每种试验在可靠性、可重复性、灵敏度和解释的简易性方面都存在一定程度的不足。本综述涵盖了已报道和描述的那些试验，并突出了它们的一些优点和缺点。
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