代谢途径与酶数据库
The MetaCyc Database.
作者信息
Karp Peter D, Riley Monica, Paley Suzanne M, Pellegrini-Toole Alida
机构信息
Bioinformatics Research Group, SRI International, 333 Ravenswood Avenue EK207, Menlo Park, CA 94025, USA.
出版信息
Nucleic Acids Res. 2002 Jan 1;30(1):59-61. doi: 10.1093/nar/30.1.59.
MetaCyc is a metabolic-pathway database that describes 445 pathways and 1115 enzymes occurring in 158 organisms. MetaCyc is a review-level database in that a given entry in MetaCyc often integrates information from multiple literature sources. The pathways in MetaCyc were determined experimentally, and are labeled with the species in which they are known to occur based on literature references examined to date. MetaCyc contains extensive commentary and literature citations. Applications of MetaCyc include pathway analysis of genomes, metabolic engineering and biochemistry education. MetaCyc is queried using the Pathway Tools graphical user interface, which provides a wide variety of query operations and visualization tools. MetaCyc is available via the World Wide Web at http://ecocyc.org/ecocyc/metacyc.html, and is available for local installation as a binary program for the PC and the Sun workstation, and as a set of flatfiles. Contact metacyc-info@ai.sri.com for information on obtaining a local copy of MetaCyc.
MetaCyc是一个代谢途径数据库，它描述了158种生物体中存在的445条途径和1115种酶。MetaCyc是一个综述级别的数据库，因为MetaCyc中的特定条目通常整合了来自多个文献来源的信息。MetaCyc中的途径是通过实验确定的，并根据迄今为止查阅的文献参考文献，标记出已知其存在的物种。MetaCyc包含大量的注释和文献引用。MetaCyc的应用包括基因组的途径分析、代谢工程和生物化学教育。使用Pathway Tools图形用户界面查询MetaCyc，该界面提供了各种各样的查询操作和可视化工具。可通过万维网在http://ecocyc.org/ecocyc/metacyc.html上获取MetaCyc，它也可作为适用于PC和Sun工作站的二进制程序以及一组平面文件进行本地安装。如需获取MetaCyc本地副本的信息，请联系metacyc-info@ai.sri.com。
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