• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

MetaCyc 数据库包含代谢途径和酶，以及 BioCyc 集合的途径/基因组数据库。

The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases.

机构信息

SRI International, 333 Ravenswood, Menlo Park, CA 94025, USA, USA.

出版信息

Nucleic Acids Res. 2012 Jan;40(Database issue):D742-53. doi: 10.1093/nar/gkr1014. Epub 2011 Nov 18.

DOI:10.1093/nar/gkr1014
PMID:22102576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3245006/
Abstract

The MetaCyc database (http://metacyc.org/) provides a comprehensive and freely accessible resource for metabolic pathways and enzymes from all domains of life. The pathways in MetaCyc are experimentally determined, small-molecule metabolic pathways and are curated from the primary scientific literature. MetaCyc contains more than 1800 pathways derived from more than 30,000 publications, and is the largest curated collection of metabolic pathways currently available. Most reactions in MetaCyc pathways are linked to one or more well-characterized enzymes, and both pathways and enzymes are annotated with reviews, evidence codes and literature citations. BioCyc (http://biocyc.org/) is a collection of more than 1700 organism-specific Pathway/Genome Databases (PGDBs). Each BioCyc PGDB contains the full genome and predicted metabolic network of one organism. The network, which is predicted by the Pathway Tools software using MetaCyc as a reference database, consists of metabolites, enzymes, reactions and metabolic pathways. BioCyc PGDBs contain additional features, including predicted operons, transport systems and pathway-hole fillers. The BioCyc website and Pathway Tools software offer many tools for querying and analysis of PGDBs, including Omics Viewers and comparative analysis. New developments include a zoomable web interface for diagrams; flux-balance analysis model generation from PGDBs; web services; and a new tool called Web Groups.

摘要

MetaCyc 数据库（http://metacyc.org/）提供了一个全面且可免费获取的资源，其中包含来自所有生命领域的代谢途径和酶。MetaCyc 中的途径是经过实验确定的、小分子代谢途径，并从主要科学文献中进行了整理。MetaCyc 包含了超过 1800 条来自超过 30000 篇文献的途径，是目前可获得的最大经过整理的代谢途径集合。MetaCyc 途径中的大多数反应都与一个或多个特征明确的酶有关，并且途径和酶都经过了综述、证据代码和文献引用的注释。BioCyc（http://biocyc.org/）是一个包含超过 1700 个特定生物体的途径/基因组数据库（PGDB）的集合。每个 BioCyc PGDB 都包含一个生物体的完整基因组和预测代谢网络。该网络是由 Pathway Tools 软件使用 MetaCyc 作为参考数据库进行预测的，由代谢物、酶、反应和代谢途径组成。BioCyc PGDB 还包含其他功能，包括预测操纵子、运输系统和途径填补物。BioCyc 网站和 Pathway Tools 软件提供了许多用于查询和分析 PGDB 的工具，包括 Omics Viewer 和比较分析。新的发展包括用于图表的可缩放 Web 界面；从 PGDB 生成通量平衡分析模型；Web 服务；以及一个名为 Web Groups 的新工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/3025c24f9c55/gkr1014f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/5a6dfe5d18d2/gkr1014f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/6be875f870d9/gkr1014f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/00bc4ef32d81/gkr1014f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/efee48494331/gkr1014f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/9efdd656a510/gkr1014f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/3025c24f9c55/gkr1014f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/5a6dfe5d18d2/gkr1014f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/6be875f870d9/gkr1014f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/00bc4ef32d81/gkr1014f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/efee48494331/gkr1014f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/9efdd656a510/gkr1014f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b5/3245006/3025c24f9c55/gkr1014f6.jpg

相似文献

1
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases.MetaCyc 数据库包含代谢途径和酶，以及 BioCyc 集合的途径/基因组数据库。
Nucleic Acids Res. 2012 Jan;40(Database issue):D742-53. doi: 10.1093/nar/gkr1014. Epub 2011 Nov 18.
2
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases.MetaCyc 数据库包含代谢途径和酶，以及 BioCyc 集合的途径/基因组数据库。
Nucleic Acids Res. 2010 Jan;38(Database issue):D473-9. doi: 10.1093/nar/gkp875. Epub 2009 Oct 22.
3
The MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases.代谢途径与酶的MetaCyc数据库以及途径/基因组数据库的BioCyc集合。
Nucleic Acids Res. 2008 Jan;36(Database issue):D623-31. doi: 10.1093/nar/gkm900. Epub 2007 Oct 27.
4
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases.代谢途径与酶的MetaCyc数据库以及途径/基因组数据库的BioCyc集合。
Nucleic Acids Res. 2016 Jan 4;44(D1):D471-80. doi: 10.1093/nar/gkv1164. Epub 2015 Nov 2.
5
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases.MetaCyc 数据库包含代谢途径和酶，以及 BioCyc 集合的途径/基因组数据库。
Nucleic Acids Res. 2014 Jan;42(Database issue):D459-71. doi: 10.1093/nar/gkt1103. Epub 2013 Nov 12.
6
The MetaCyc database of metabolic pathways and enzymes.MetaCyc 数据库中的代谢途径和酶。
Nucleic Acids Res. 2018 Jan 4;46(D1):D633-D639. doi: 10.1093/nar/gkx935.
7
MetaCyc: a multiorganism database of metabolic pathways and enzymes.MetaCyc：一个多生物体代谢途径和酶的数据库。
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D511-6. doi: 10.1093/nar/gkj128.
8
The MetaCyc database of metabolic pathways and enzymes - a 2019 update.代谢途径和酶的 MetaCyc 数据库——2019 年更新。
Nucleic Acids Res. 2020 Jan 8;48(D1):D445-D453. doi: 10.1093/nar/gkz862.
9
Expansion of the BioCyc collection of pathway/genome databases to 160 genomes.将BioCyc通路/基因组数据库集合扩展至160个基因组。
Nucleic Acids Res. 2005 Oct 24;33(19):6083-9. doi: 10.1093/nar/gki892. Print 2005.
10
MetaCyc: a multiorganism database of metabolic pathways and enzymes.MetaCyc：一个关于代谢途径和酶的多生物体数据库。
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D438-42. doi: 10.1093/nar/gkh100.

引用本文的文献

1
Effects of choline metabolite-trimethylamine N-oxide on immunometabolism in inflammatory bowel disease.胆碱代谢产物——氧化三甲胺对炎症性肠病免疫代谢的影响。
Front Immunol. 2025 Jul 17;16:1591151. doi: 10.3389/fimmu.2025.1591151. eCollection 2025.
2
Metabolic reprogramming and functional crosstalk within the tumor microenvironment (TME) and A Multi-omics anticancer approach.肿瘤微环境（TME）中的代谢重编程与功能串扰以及多组学抗癌方法。
Med Oncol. 2025 Jul 24;42(9):373. doi: 10.1007/s12032-025-02945-5.
3
The Importance of Vitamin D and Magnesium in Athletes.

本文引用的文献

1
Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development.用于生物燃料开发的罗尔斯通氏菌 PD630 的比较和功能基因组学。
PLoS Genet. 2011 Sep;7(9):e1002219. doi: 10.1371/journal.pgen.1002219. Epub 2011 Sep 8.
2
Proteomic characterization of cellular and molecular processes that enable the Nanoarchaeum equitans--Ignicoccus hospitalis relationship.纳米古菌-火球菌共生关系中细胞和分子过程的蛋白质组学特征。
PLoS One. 2011;6(8):e22942. doi: 10.1371/journal.pone.0022942. Epub 2011 Aug 3.
3
Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum.
维生素D和镁对运动员的重要性。
Nutrients. 2025 May 13;17(10):1655. doi: 10.3390/nu17101655.
4
Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.短期补充镁对自行车测力计运动表现和骨骼肌线粒体有适度的不利影响，对肠道微生物群的影响可忽略不计：一项随机交叉临床试验。
Nutrients. 2025 Mar 6;17(5):915. doi: 10.3390/nu17050915.
5
Magnesium and Migraine.镁与偏头痛
Nutrients. 2025 Feb 18;17(4):725. doi: 10.3390/nu17040725.
6
Mineral Supplements in Ageing.衰老过程中的矿物质补充剂
Subcell Biochem. 2024;107:269-306. doi: 10.1007/978-3-031-66768-8_13.
7
Magnesium depletion score and gout: insights from NHANES data.镁缺乏评分与痛风：来自美国国家健康与营养检查调查（NHANES）数据的见解
Front Nutr. 2024 Nov 21;11:1485578. doi: 10.3389/fnut.2024.1485578. eCollection 2024.
8
Elucidating the Functional Roles of Long Non-Coding RNAs in Alzheimer's Disease.阐明长链非编码 RNA 在阿尔茨海默病中的功能作用。
Int J Mol Sci. 2024 Aug 25;25(17):9211. doi: 10.3390/ijms25179211.
9
Carbapenem-resistant Acinetobacter baumannii (CRAB): metabolic adaptation and transcriptional response to human urine (HU).耐碳青霉烯鲍曼不动杆菌（CRAB）：对人尿（HU）的代谢适应和转录反应。
Sci Rep. 2024 Aug 19;14(1):19145. doi: 10.1038/s41598-024-70216-w.
10
Low magnesium in conjunction with high homocysteine increases DNA damage in healthy middle aged Australians.低镁血症与高同型半胱氨酸血症增加了澳大利亚健康中年人的 DNA 损伤。
Eur J Nutr. 2024 Oct;63(7):2555-2565. doi: 10.1007/s00394-024-03449-0. Epub 2024 Jun 12.
突变型醇脱氢酶可提高产热梭菌的乙醇耐受性。
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13752-7. doi: 10.1073/pnas.1102444108. Epub 2011 Aug 8.
4
Genome-wide mutagenesis of Xanthomonas axonopodis pv. citri reveals novel genetic determinants and regulation mechanisms of biofilm formation.柑橘溃疡病菌全基因组诱变揭示了生物膜形成的新的遗传决定因素和调控机制。
PLoS One. 2011;6(7):e21804. doi: 10.1371/journal.pone.0021804. Epub 2011 Jul 5.
5
Large-scale comparative phenotypic and genomic analyses reveal ecological preferences of shewanella species and identify metabolic pathways conserved at the genus level.大规模比较表型和基因组分析揭示了希瓦氏菌属物种的生态偏好，并确定了在属水平上保守的代谢途径。
Appl Environ Microbiol. 2011 Aug;77(15):5352-60. doi: 10.1128/AEM.00097-11. Epub 2011 Jun 3.
6
Web-based metabolic network visualization with a zooming user interface.基于网络的代谢网络可视化，具有缩放用户界面。
BMC Bioinformatics. 2011 May 19;12:176. doi: 10.1186/1471-2105-12-176.
7
Clostridium difficile transcriptome analysis using pig ligated loop model reveals modulation of pathways not modulated in vitro.应用猪结扎肠袢模型进行艰难梭菌转录组分析揭示了体外未调节途径的调节。
J Infect Dis. 2011 Jun 1;203(11):1613-20. doi: 10.1093/infdis/jir112.
8
Comparative genomics of cell envelope components in mycobacteria.分枝杆菌细胞包膜成分的比较基因组学。
PLoS One. 2011 May 6;6(5):e19280. doi: 10.1371/journal.pone.0019280.
9
The impact of oxygen on the transcriptome of recombinant S. cerevisiae and P. pastoris - a comparative analysis.氧气对重组酿酒酵母和巴斯德毕赤酵母转录组的影响——比较分析。
BMC Genomics. 2011 May 9;12:218. doi: 10.1186/1471-2164-12-218.
10
Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strains.两株假结核棒状杆菌中还原基因组进化和毒力功能横向获得的证据。
PLoS One. 2011 Apr 18;6(4):e18551. doi: 10.1371/journal.pone.0018551.