含雌激素口服避孕药对尿硫酸皮质类固醇排泄的影响。

Effect of estrogen-containing oral contraceptives on urinary corticosteroid sulfate excretion.

作者信息

Fahl W E, Rose D P

出版信息

Clin Chim Acta. 1975 Sep 1;63(2):189-92. doi: 10.1016/0009-8981(75)90161-8.

Abstract

The excretion of corticosteroid sulfates and free cortisol in urine, and the total plasma cortisol, have been determined in 41 women receiving an estrogen-containing oral contraceptive and 53 age-matched female controls. The contraceptive steroids caused increases in the urinary corticosteroid sulfates and plasma cortisol similar to those observed in pregnancy; urinary free cortiscol was unchanged.

摘要

对41名服用含雌激素口服避孕药的女性和53名年龄匹配的女性对照者测定了尿中皮质类固醇硫酸盐和游离皮质醇的排泄量以及血浆总皮质醇水平。避孕药类固醇导致尿中皮质类固醇硫酸盐和血浆皮质醇增加，与妊娠时观察到的情况相似；尿中游离皮质醇未发生变化。