几种苯并咪唑类杀菌剂与α-和β-环糊精的络合作用。

Complexation of several benzimidazole-type fungicides with alpha- and beta-cyclodextrins.

作者信息

Lezcano Minerva, Al-Soufi Wajih, Novo Mercedes, Rodríguez-Núñez Eugenio, Tato José Vázquez

机构信息

Departamentos de Química Física y Física Aplicada, Facultade de Ciencias, Universidade de Santiago de Compostela, E-27002 Lugo, Spain.

出版信息

J Agric Food Chem. 2002 Jan 2;50(1):108-12. doi: 10.1021/jf010927y.

DOI:10.1021/jf010927y

PMID:11754552

Abstract

The potential increase in water solubility of three benzimidazole-type fungicides (thiabendazole, carbendazim, and fuberidazole) due to complexation with alpha- and beta-cyclodextrins was investigated. Fluorescence emission spectra of the fungicides in the presence of different concentrations of the cyclodextrins were measured. Analysis of these spectra by the method of principal components global analysis (PCGA) yielded precise values for the association constants and the emission spectra of the fungicide-cyclodextrin inclusion complexes. Phase-solubility diagrams confirmed the formation of inclusion complexes between each of the fungicides and beta-cyclodextrin and showed significant increases of their solubilities due to complexation.

摘要

研究了三种苯并咪唑类杀菌剂（噻菌灵、多菌灵和呋菌唑）与α-和β-环糊精络合后水溶性的潜在增加情况。测量了在不同浓度环糊精存在下杀菌剂的荧光发射光谱。通过主成分全局分析（PCGA）方法对这些光谱进行分析，得出了杀菌剂-环糊精包合物的缔合常数和发射光谱的精确值。相溶解度图证实了每种杀菌剂与β-环糊精之间形成了包合物，并表明由于络合作用它们的溶解度显著增加。