沙门氏菌诱导产生的一氧化氮（NO）对宿主防御及疫苗的影响：NO，一种具有抗菌、抗肿瘤、免疫抑制及免疫调节作用的分子。
Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule.
作者信息
Eisenstein T K
机构信息
Department of Microbiology and Immunology, and Center for Substance Abuse Research, 3400 North Broad Street, Temple University School of Medicine, Philadelphia, PA 19140, USA.
出版信息
Microbes Infect. 2001 Nov-Dec;3(14-15):1223-31. doi: 10.1016/s1286-4579(01)01482-4.
Attenuated Salmonella induce immunosuppressive, microbicidal and tumoricidal macrophages in mice. All three effects are mediated by activated macrophages producing nitric oxide (NO). NO is induced by the innate immune response pathway involving IL-12, NK cells and IFN-gamma in response to infection. NO has beneficial and detrimental effects on the host.
减毒沙门氏菌可在小鼠体内诱导产生具有免疫抑制、杀菌和杀肿瘤作用的巨噬细胞。这三种作用均由产生一氧化氮（NO）的活化巨噬细胞介导。NO是由涉及白细胞介素-12、自然杀伤细胞和干扰素-γ的先天性免疫反应途径在感染应答中诱导产生的。NO对宿主具有有益和有害的影响。
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