Hemler M E
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
J Cell Biol. 2001 Dec 24;155(7):1103-7. doi: 10.1083/jcb.200108061.
Relatively little attention has been given to the large family of abundantly expressed transmembrane proteins known as tetraspanins. Now, the importance of tetraspanins is strongly supported by emerging genetic evidence, coupled with new insights into the biochemistry and functions of tetraspanin protein complexes.
相对而言,人们对大量表达的跨膜蛋白大家族四跨膜蛋白关注较少。如今,新出现的遗传学证据有力地支持了四跨膜蛋白的重要性,同时也为四跨膜蛋白复合物的生物化学和功能带来了新的见解。