白塞病患者一氧化氮生成增加：它是一种新的活动标志物吗？

Increased nitric oxide production in patients with Behçet's disease: is it a new activity marker?

作者信息

Evereklioglu Cem, Turkoz Yusuf, Er Hamdi, Inaloz H Serhat, Ozbek Emin, Cekmen Mustafa

机构信息

Departments of Ophthalmology, Gaziantep University Medical Faculty, Research Hospital, Gaziantep, Turkey.

出版信息

J Am Acad Dermatol. 2002 Jan;46(1):50-4. doi: 10.1067/mjd.2002.118338.

DOI:10.1067/mjd.2002.118338

PMID:11756945

Abstract

BACKGROUND

The origin of Behçet's disease (BD) is unclear. One of the prominent features of BD is vasculitis and thrombosis as a result of endothelial dysfunction. Because nitric oxide (NO) is synthesized by endothelium, we considered it as an interesting target of investigation in BD.

OBJECTIVE

Our purpose was to define the level of NO in the serum of patients with BD and its relation with disease activity.

METHODS

As an indicator for NO, serum total nitrite levels (end product of NO) were measured by Griess reaction in 52 consecutive patients with BD and compared with 32 age- and sex-matched healthy staff volunteers. Serum NO levels of active and inactive patients were compared.

RESULTS

The overall serum nitrite levels in patients with BD (40.25 +/- 10.51 micromol/L) were significantly higher (P <.001) than those in healthy volunteers (25.09 +/- 5.33 micromol/L). The difference in serum total nitrite levels among patients with active BD (46.74 +/- 10.62 micromol/L) and inactive BD (33.24 +/- 3.73 micromol/L) was significant (P <.001). Significant differences were observed in serum nitrite levels between patients in the inactive period of BD and the control group (P <.001).

CONCLUSION

Increased NO production might be responsible for the overall inflammatory process of BD. NO seems to be related to disease activity.

摘要

背景

白塞病（BD）的病因尚不清楚。BD的一个显著特征是血管炎和由于内皮功能障碍导致的血栓形成。由于一氧化氮（NO）由内皮细胞合成，我们认为它是BD中一个值得研究的有趣靶点。

目的

我们的目的是确定BD患者血清中NO的水平及其与疾病活动的关系。

方法

作为NO的指标，通过格里斯反应测定了52例连续的BD患者血清中的总亚硝酸盐水平（NO的终产物），并与32名年龄和性别匹配的健康工作人员志愿者进行了比较。比较了活动期和非活动期患者的血清NO水平。

结果

BD患者的总体血清亚硝酸盐水平（40.25±10.51微摩尔/升）显著高于健康志愿者（25.09±5.33微摩尔/升）（P<.001）。活动期BD患者（46.74±10.62微摩尔/升）和非活动期BD患者（33.24±3.73微摩尔/升）的血清总亚硝酸盐水平差异显著（P<.001）。BD非活动期患者与对照组之间的血清亚硝酸盐水平存在显著差异（P<.001）。