白塞病患者血浆肾上腺髓质素水平升高。

Increased plasma adrenomedullin levels in patients with Behçet's disease.

作者信息

Evereklioglu C, Yurekli M, Er H, Ozbek E, Hazneci E, Cekmen M, Inaloz H S

机构信息

Department of Ophthalmology, Research Hospital, Gaziantep University School of Medicine, Gaziantep, Turkey.

出版信息

Dermatology. 2000;201(4):312-5. doi: 10.1159/000051544.

DOI:10.1159/000051544

PMID:11146340

Abstract

BACKGROUND

Behçet's disease (BD) is a chronic systemic inflammatory disorder affecting multiple organs with a generalized vasculitis of arteries and veins. Endothelial dysfunction is one of the prominent features of BD. Adrenomedullin (AM) is a peptide produced not only in normal adrenal medulla but also in the vascular smooth muscle cells and endothelial cells, and its role in the course of BD has not been previously described.

OBJECTIVE

To detect changes of plasma AM concentrations in patients with BD compared with age- and sex-matched healthy subjects by using high-performance liquid chromatography (HPCL). We also investigated if disease activity or the duration of BD correlates with AM levels.

METHODS

Forty-two consecutive patients with BD (38.5 +/- 11.1 years, 19 male and 23 female) and 20 healthy age- and sex-matched control subjects (39.5 +/- 10.9 years, 8 male and 12 female) were included in this study. We measured plasma AM levels by HPCL, and acute-phase reactants including alpha(1)-antitrypsin and alpha(2)-macroglobulin, neutrophil count and the erythrocyte sedimentation rate.

RESULTS

Mean +/- SD plasma AM levels in patients with BD (73.22 +/- 25.55 pmol/l) were significantly higher (p < 0.001) than in healthy control volunteers (21.35 +/- 12.37 pmol/l). Patients with active BD had similar plasma AM concentrations (79.32 +/- 21.89 pmol/l) with patients with inactive disease (67.44 +/- 29.92 pmol/l). On the other hand, patients with longer duration of the disease (mean duration, 13.9 +/- 3.8 years) had significantly higher plasma AM levels (83.99 +/- 19.71 pmol/l; p = 0.005) than patients (62.45 +/- 26.57 pmol/l) with shorter duration of the disease (mean duration, 5. 5 +/- 2.3 years). All acute-phase reaction parameters were found to be significantly increased in the active disease.

CONCLUSION

Considering its endothelial cell implications, AM may be involved in reparatory vessel endothelium mechanisms, especially in the chronic disease.

摘要

背景

白塞病（BD）是一种慢性全身性炎症性疾病，可累及多个器官，伴有动脉和静脉的全身性血管炎。内皮功能障碍是BD的突出特征之一。肾上腺髓质素（AM）是一种不仅在正常肾上腺髓质中产生，也在血管平滑肌细胞和内皮细胞中产生的肽，其在BD病程中的作用此前尚未见报道。

目的

通过高效液相色谱法（HPCL）检测BD患者与年龄和性别匹配的健康受试者相比血浆AM浓度的变化。我们还研究了疾病活动度或BD病程是否与AM水平相关。

方法

本研究纳入了42例连续的BD患者（38.5±11.1岁，男性19例，女性23例）和20例年龄和性别匹配的健康对照受试者（39.5±10.9岁，男性8例，女性12例）。我们通过HPCL测量血浆AM水平，以及急性期反应物，包括α1-抗胰蛋白酶和α2-巨球蛋白、中性粒细胞计数和红细胞沉降率。

结果

BD患者的平均±标准差血浆AM水平（73.22±25.55 pmol/l）显著高于健康对照志愿者（21.35±12.37 pmol/l，p<0.001）。活动期BD患者的血浆AM浓度（79.32±21.89 pmol/l）与非活动期疾病患者（67.44±29.92 pmol/l）相似。另一方面，病程较长的患者（平均病程13.9±3.8年）的血浆AM水平（83.99±19.71 pmol/l；p = 0.005）显著高于病程较短的患者（平均病程5.5±2.3年，62.45±26.57 pmol/l）。在活动期疾病中，所有急性期反应参数均显著升高。