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[百草枯中毒患者肾脏活检的超微结构研究]

[Ultrastructural study of a renal biopsy in a patient poisoned by paraquat].

作者信息

Bescol-Liversac J, Paquelin A, Guillam C

出版信息

Eur J Toxicol Environ Hyg. 1975 Jul-Aug;8(4):236-46.

PMID:1175700
Abstract

It is possible through investigation under the electronic microscope to determine the location and nature of lesions with accuracy. These lesions are mainly found on the epithelium of proximal and distal convoluted tubules. However, the extent of lesions together with the deterioration process of the cell-constituents vary from one structure to the other and even from cell to cell. On the other hand, while blood capillary vessels pertaining to tubules may also show moderate lesions, glomerular and interstitial deterioration is rare. Kidney deterioration which may either result directly from one of the poison effects or from related phenomena, is under discussion.

摘要

通过电子显微镜下的研究能够准确确定病变的位置和性质。这些病变主要见于近端和远端曲管的上皮。然而,病变的程度以及细胞成分的恶化过程因结构不同而异,甚至细胞与细胞之间也有差异。另一方面,虽然与肾小管相关的毛细血管也可能呈现中度病变,但肾小球和间质的恶化很少见。肾脏恶化可能直接由中毒效应之一或相关现象导致,对此正在进行讨论。

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