Kamphuisen P W, Eikenboom H C, Rosendaal F R, Bertina R M
Thans: Ziekenhuis Rijnstate, afd. Inwendige Geneeskunde, Postbus 9555, 6800 TA Arnhem.
Ned Tijdschr Geneeskd. 2001 Nov 17;145(46):2213-7.
Several case-control studies have shown that factor VIII levels > or = 150 IU/100 ml lead to a greatly increased risk of venous thrombosis. High levels of factor VIII are also associated with an increased risk of recurrences of thrombosis. The prevalence of high factor VIII levels is 25% in patients with a first episode of venous thrombosis and 11% among healthy controls. The contribution of high factor VIII levels to the onset of venous thrombosis in the population is 16%. The mechanism causing high factor VIII levels is largely unknown and probably consists of both genetic and acquired factors. At present, the routine screening of thrombosis patients for high factor VIII levels is not recommended.
多项病例对照研究表明，凝血因子 VIII 水平≥150 IU/100 ml会导致静脉血栓形成风险大幅增加。高凝血因子 VIII 水平还与血栓复发风险增加有关。在首次发生静脉血栓的患者中，高凝血因子 VIII 水平的患病率为25%，在健康对照者中为11%。高凝血因子 VIII 水平在人群中对静脉血栓形成的促成作用为16%。导致高凝血因子 VIII 水平的机制在很大程度上尚不清楚，可能由遗传和后天因素共同构成。目前，不建议对血栓形成患者常规筛查高凝血因子 VIII 水平。
