Sinawat S, Chiyabutra T, Kleabkaew P
Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Thailand.
J Med Assoc Thai. 2001 Jul;84(7):1033-6.
Breast cancer is among the commonest malignancies in women and tamoxifen has been widely used for more than two decades for treatment of breast cancer. It has been known that long term use of tamoxifen significantly increases the risk of endometrial cancer but there is no generally accepted recommendation regarding the surveillance of endometrial pathologies in breast cancer patients taking tamoxifen. Although the incidence of endometrial cancer associated with tamoxifen use is not high, the risk is true and these patients could be helped by screening methods such as transvaginal ultrasonogrphy. We report here a case of endometrial cancer detected by transvaginal 2D scan in an asymptomatic postmenopausal woman taking tamoxifen.
乳腺癌是女性最常见的恶性肿瘤之一，他莫昔芬已被广泛用于治疗乳腺癌二十多年。众所周知，长期使用他莫昔芬会显著增加子宫内膜癌的风险，但对于服用他莫昔芬的乳腺癌患者子宫内膜病变的监测，尚无普遍接受的建议。虽然与使用他莫昔芬相关的子宫内膜癌发病率不高，但风险是真实存在的，经阴道超声检查等筛查方法可能有助于这些患者。我们在此报告一例在服用他莫昔芬的无症状绝经后妇女中经阴道二维扫描检测出子宫内膜癌的病例。
