Szabó P, Tóth M, Horányi J, Rácz K, Gláz E, Tulassay Z
Altalános Orvostudományi Kar II. Belgyógyászati Klinika, Semmelweis Egyetem, Budapest.
Orv Hetil. 2001 Oct 14;142(41):2251-4.
The aim of this study was the analysis and comparison of bone density data obtained by dual-energy X-ray absorptiometry (DEXA) and quantitative ultrasound (QUS) and the follow up of bone density after parathyroidectomy of our patients with primary hyperparathyroidism. The authors performed bone mineral density (BMD) measurements using DEXA (Hologic QDR 4500 C) and QUS (Lunar Achilles Plus) devices in 22 patients with primary hyperparathyroidism between 1997 and 1999 (19 sporadic, 1 MEN 1., 2 MEN II.). Fifteen patients underwent parathyroidectomy (13 adenoma, 2 carcinoma). According to DEXA measurements all patients had osteoporosis. The lowest bone mineral density was detected at the wrist: the mean t-score was -4.00 +/- 1.79. After parathyroidectomy nine patients were followed for a mean of 12.8 months. After one year following surgery the most significant increase in BMD was 14.6%. The QUS values did not correlate with the DEXA data before the operation and no significant changes in stiffness were detected after surgery. The QUS values do not reflect the severity of the BMD decrease by DEXA in patients with primary hyperparathyroidism.
本研究旨在分析和比较通过双能X线吸收法（DEXA）和定量超声（QUS）获得的骨密度数据，并对原发性甲状旁腺功能亢进患者甲状旁腺切除术后的骨密度进行随访。作者于1997年至1999年间，使用DEXA（Hologic QDR 4500 C）和QUS（Lunar Achilles Plus）设备对22例原发性甲状旁腺功能亢进患者（19例散发性，1例MEN 1型，2例MEN II型）进行了骨矿物质密度（BMD）测量。15例患者接受了甲状旁腺切除术（13例腺瘤，2例癌）。根据DEXA测量，所有患者均患有骨质疏松症。腕部骨矿物质密度最低：平均t值为-4.00±1.79。甲状旁腺切除术后，对9例患者进行了平均12.8个月的随访。术后一年，BMD最显著的增加为14.6%。术前QUS值与DEXA数据不相关，术后未检测到硬度有显著变化。在原发性甲状旁腺功能亢进患者中，QUS值不能反映DEXA所显示的BMD降低的严重程度。
