Popkova A M, Rasheva V I, Tolchkov E V, Alatortsev V E
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia.
Genetika. 2001 Oct;37(10):1430-4.
The effects of suppressors of position-effect variegation were studied in a set of euchromatin-heterochromatin rearrangements of the X chromosome accompanied by inactivation of the gene wapl. The rearrangements differed from one another in the size of the heterochromatic block adjacent to euchromatin, with the euchromatin-heterochromatin border remaining unchanged. In one rearrangement (r20), the position effect caused by a small block of adjacent heterochromatin may be determined by its interaction with the neighboring main heterochromatic region of the X chromosome. Chromosome 3 (the RT chromosome) was found to have a strong suppressing effect on all rearrangements, irrespective of the amount of heterochromatin adjacent to euchromatin. Su-var(3)9, a known suppressor of the position-effect variegation, had a considerably weaker suppressing effect. The RT chromosome had the strongest suppressing effect on the rearrangement r20.
在一组伴随wapl基因失活的X染色体常染色质-异染色质重排中,研究了位置效应斑驳抑制因子的作用。这些重排在与常染色质相邻的异染色质块大小上彼此不同,而常染色质-异染色质边界保持不变。在一种重排(r20)中,由一小段相邻异染色质块引起的位置效应可能由其与X染色体相邻的主要异染色质区域的相互作用决定。发现3号染色体(RT染色体)对所有重排都有很强的抑制作用,而与常染色质相邻的异染色质数量无关。已知的位置效应斑驳抑制因子Su-var(3)9的抑制作用要弱得多。RT染色体对重排r20的抑制作用最强。