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孕期缺水对第一代和第二代大鼠子代水盐组织成分及肾功能的影响

[Effect of the water deprivation during pregnancy on the water-salt tissue composition and kidney function in the rat offspring of the first and second generation].

作者信息

Kushner S R, Iglina N G, Aĭzman R I

机构信息

Pedagogical University, Novosibirk, 630126, Russia.

出版信息

Ross Fiziol Zh Im I M Sechenova. 2001 Sep;87(9):1184-92.

PMID:11763531
Abstract

Rats were subjected to intermittent water restriction from the 1st day of pregnancy until delivery. Water, sodium, and potassium contents in the liver, brain, skeletal muscles, heart, kidneys, and subcutaneous fat tissue were determined in the litter. Water and sodium contents in 30-day old rats of the 1st and 2nd generation were found to be comparable to the control values. Water loading resulted in weaker diuretic responses in the former rats as compared with the control. No differences in the renal response were revealed in adult rats.

摘要

从怀孕第1天到分娩,对大鼠进行间歇性限水。测定了幼崽肝脏、大脑、骨骼肌、心脏、肾脏和皮下脂肪组织中的水、钠和钾含量。发现第一代和第二代30日龄大鼠的水和钠含量与对照值相当。与对照组相比,水负荷使前一组大鼠的利尿反应较弱。在成年大鼠中未发现肾脏反应有差异。

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