Silberbauer K, Pietschmann H, Sinzinger H, Ring F
Wien Klin Wochenschr. 1979 Nov 23;91(22):755-8.
This study of 20 patients with monoclonal gammopathy (17 patients with multiple myeloma and 3 patients with Waldenström's syndrome) showed a decreased platlet aggregation induced by ADP and collagen, a reduced platlet retention and a prolonged bleeding time in 25% of the cases in comparison with 30 age- and sex-matched healthy controls. Using Wu and Hoak's technique as increased number of reversible platelet aggregates was observed. There was no relationship between the parameters of primary haemostasis and protein analysis. A disturbed mechanism of primary haemostasis is the main factor responsible for the bleeding diathesis in patients with monoclonal gammopathy.
这项对20例单克隆丙种球蛋白病患者（17例多发性骨髓瘤患者和3例华氏巨球蛋白血症患者）的研究表明，与30名年龄和性别匹配的健康对照相比，25%的病例中由ADP和胶原蛋白诱导的血小板聚集减少、血小板滞留减少且出血时间延长。采用吴和霍克的技术，观察到可逆性血小板聚集体数量增加。原发性止血参数与蛋白质分析之间没有关系。原发性止血机制紊乱是单克隆丙种球蛋白病患者出血素质的主要原因。
